Department of Bioinformatics – Central University of South Bihar

About Department

Vision and Mission

Academic Program

Faculty

Facilities

Student

Research

eResource

Contact

Bioinformatics 2016 workshop drug design

Bioinformatics is a rapidly growing interdisciplinary field of study, involving multiple disciplines of biology, chemistry, physics, mathematics, statistics, pharmaceutical & computer sciences, and information technology. It has wide-ranging applications from marker development and diagnostics to drug discovery and toxicological predictions. To mention few, modeling, simulation and AI techniques, drug lead predictions and optimization, are the most sought-after skills for job-seekers in pharmaceutical and biomedical industries.

With a purpose to open a new department in this frontier area, the foundation of the department was laid in 2011 and for a while it continued as an independent Bioinformatics Programme within the-then Centre for Biological Sciences. In 2018, it acquired full-fledged department status. It is the only department in the entire state of Bihar, and one of the few places of higher learning in Eastern India to promote teaching and research in Bioinformatics & computational sciences.

The department offers two programs: (i) MSc in Bioinformatics, and (ii) PhD in Bioinformatics. In these programmes, the students are trained for various scientific methods and tools, enabling them to better suit for different research laboratories and industries, which require manpower skilled in programming languages, data analytics, machine learning techniques, computational modeling and drug design. Students are provided support and encouragement to gain experience in the department, as well as in established labs in the country, for their project work and to publish their research.

Department Overview

Established in	2011 (Initially named as Centre for Biological Sciences (Bioinformatics) and since 2018 name changed to Department of Bioinformatics
Employee Strength	Faculty- 07 Staffs - 02
Student Strength	Research Scholar & JRF-19 PG-Students -58 MPhil/PhD Graduated - 02
Placement 2022 (Job, Higher Studies)	10 (tentative)
Publications & Patent (Last 5-Years)	Publications- 101 Patent -02 Books - 04

News and Announcements

List of Mentors

MSc Students 2020-22

MSc Students 2021-23
Congratulations on Placement
MSc (2019-21) Batch Students

Important Links

About Statutory Bodies and Committees

Board of Studies (BoS)

BoS is a statutory body for each department/centre, primarily responsible for syllabus design and regular update. As described in the Ordinance section 25.10,

The functions of the Board of Studies shall be:-

To recommend to the School Board, courses of studies offered by the Department/Centre and continue updating syllabus;
To take all steps in accordance with the provisions of the Regulations about teaching and evaluation of various courses/programmes of the Department/Centre;
To recommend to the School Board measures for the improvement of teaching and research in the Department/Centre;
To constitute panels of experts to be considered for appointment as Examiners, Board of Examiners for various courses/academic programmes and M.Phil./Ph.D. thesis representing various specializations of Departments/Centres; and
To perform such other functions as may be assigned to it by the School Board, the Academic Council, the Executive Council and the Vice-Chancellor.

Department Committee (DC)

As enshrined in the Ordinace-26, the Department/Centre Committee (DC/CC) shall consist of the Head of the Department/Centre, as Chairperson ex-officio, and all faculty members of the Department/Centre.

26.2 The Department/Centre Committee shall have the following functions, namely–

To make proposals to the Board of Studies on academic programmes concerning teaching and research, and the creation, specialization and abolition of teaching posts;
To propose schemes for the maintenance and improvement of the standards of various programmes of study and research of the Department/Centre;
To apportion the teaching and co-curricular work of the Department/Centre among the teachers thereof and monitor the proper execution thereof;
To consider and decide on the assignment and utilisation of the space, equipment and other assets of the Department/Centre and other matters of general and academic interest of the Department/Centre;
To consider and recommend perspectives and major thrust areas for research and to propose research projects to be taken up by the members of the Department/Centre, individually/collectively;
To review and apprise the SRC/URC with the current status of research in Department/Centre;
To suggest to SRC/URC norms related to qualifications and research experience of a faculty to be recognized as a research degree supervisor and to constitute Department/Centre Research Degree Committee (DRC/CRC);
To suggest to University Admission, Teaching and Evaluation Committee (UATEC) on any issue related to admission, teaching, continuous evaluation in courses and students’ assessment of courses, offered by the Department/Centre to improve quality of education.
To constitute such Committee(s) comprising members of the Department/Centre, and if necessary external experts, for framing and implementation of rules and regulations related to admission, teaching, continuous evaluation, maintenance of students’ records including alumni affairs as well as promotion of research and development; and
To perform such other functions as may be assigned by the Ordinances or Regulations, or by the Vice- Chancellor/Dean/School Board from time to time.

Department Research Degree Committee (DRDC)

Departmental/Centre Research Degree Committee (DRDC/CRDC) deal with all matters connected with the Ph.D. Programme of the Department and report the matter to the University Research Degree Committee (URDC), as per University Ordinance-33. It consists of the Head of Department/Centre as Chairman and other faculties in the department.

Functions of DRDC/CRDC are as follows:

Allotment of Supervisor, Co-Supervisor, recording reasons for not admitting a candidate.
Recommendation for extension of time for submission of thesis
Recommendation to peruse a part of research outside the University
Approval of the Course Work
Assessment and Grading in Course Work
Monitoring the research progress of the candidate
Approval of Research plan proposal/language
Sanction of duty leave to the Ph.D. candidate
Assessment of Ph.D. work through pre-submission seminar
Maintaining the record of research paper publications of the candidate
11 Recommendation of panel of experts for thesis evaluation
Assessment of revised thesis for satisfactory compliance, if any
Arrangement of Viva-voce in the absence of the supervisor
Recommendation to waive the Viva-voce

Research Advisory Committee (RAC)

A Research Advisory Committee (RAC) is constituted for every research scholar admitted in PhD programme. The Committee would guide the research scholar to develop the study design and methodology of research and to To periodically review and assist in the progress of the research work of the research scholar. The committee shall have also have power to recommend the co-supervisor and cancellation of registration

Vision	To nurture young talent for global competitiveness in providing computational biology solutions and create a hub for research in bioinformatics
Mission	To inculcate self motivation and competence in graduates Imparting skills to solve biological problems using computational biology Encourage biologist to adopt computational approaches in research Provide assistance for the critical diseases Upliftment of society in general and local community in particular

MSc (Bioinformatics)

Objectives of the Program:

To serve as a nodal point for Bioinformatics and its applications
To provide industry interface to the students for research project
To build skilled manpower for drug design and pharmaceutical industry

Program Outcomes:

have a understanding of scientific methods, techniques and tools and their applications in Bioinformatics and computational sciences
be skilled in data generation, analysis and management and be able to apply the knowledge for scientific enquiry
have gained oral presentation and scientific writing skills.

Eligibility:
Intake: 45

PhD (Bioinformatics)

Objectives of the Program:

To prepare outstanding & skilled computational scientist and professionals, who could effectively translate their skills in bio, pharma and healthcare sectors, and serve in academia to provide quality training and research.

Program Outcomes:

have a comprehensive understanding of scientific methods and techniques, and their application in Bioinformatics and computational sciences;
be able to demonstrate originality in their approach in dealing with scientific problems in computational areas;
be skilled in knowledge creation, management and application, and in the planning and implementation of research
should be able to critically examine research findings and methodologies
have gained oral presentation and scientific writing skills.

Eligibility:
Intake: Subject to availability of seats as notified

Prof. R.S. Rathore

Professor

rrsrathore@cusb.ac.in, ravindranath.rathore@gmail.com

Dr. Asheesh Shanker

Professor & Head

asheesh@cusb.ac.in, ashomics@gmail.com

Dr. Ajay Kumar Singh

Associate Professor

ajaysingh@cusb.ac.in, ajjay2@gmail.com

Dr. Krishna Kumar Ojha

Assistant Professor

pkris@cub.ac.in,

Dr. Durg Vijay Singh

Assistant Professor

durgvijaysingh@cub.ac.in, dvsbiotech@gmail.com

Dr. Vijay Kumar Singh

Assistant Professor

vksingh@cub.ac.in, vksingh@cub.ac.in

Dr Anil Kumar

Assistant Professor

kumaranil@cub.ac.in, anil.bio.it@gmail.com

- Lab facility

Extensive infrastructure facilities have been developed for rigorous training and to carry out research activities. The computer labs have are equipped with latest computers of high configuration having intel i7 multi-core processors. All computers are connected with high band-width internet connection powered by 1 GBPS National Knowledge Network (NKN) of Government of India. These labs have several HP, Dell, Fujitsu & Tyrone workstations and servers for high performance computing.

- List of instruments& Softwares in the Lab
  - Multiple HP and Dell workstations and servers
  - 26-intel i7 desktop computers
  - Accelrys, Schrodinger, AMBER & various open source/commercial softwares
- Lab staffs and their contact
  - Priyatam Manohar Mrinal – Laboratory Attendant
    Qualification: B.Sc.( Zoology)
    Email: priyatammrinal@cub.ac.in
    Contact: 0631-2229-
  - Atul Kumar Tripathi – Laboratory Attendant
    Qualification: M.Sc.
    Email: atulkumar@cub.ac.in
    Contact: 0631-2229-

PG Toppers

S.No.	Year	Session	Enrollment no	Name	CGPA
1	2021	2019-21	CUSB1903312016	Nikita Krishna	8.67
2	2020	2018-20	CUSB1803312018	Sanjay Kumar Mohanty	9.54
3	2019	2017-19	CUSB1703122009	Kriti Kumari	8.00
4	2018	2016-18	CUSB1603122008	Prasun Kumar Dev	8.19
5	2017	2015-17	CUSB1403122008	Priyanka Rani	8.17
6	2016	2014-16	CUSB1403122021	Shweta Kumari	9.00
7	2015	2013-15	CUSB13312016
8	2014	2012-14	CUSB1203312016

Post Doc. Fellow Ph. D Research Scholar & Project Staff

S.No.	Research Scholar/JRF/Project staff	Guide	Academic Qualification	Research Area	Achievement/Award /Publication
1	Rakesh Kumar rakeshbis@cub.ac.in CUSB1503175001 Contact:7870783312	Dr. Vijay Kr. Singh	M.Phil. in Bioinformatics	Functional Genomics & microarray/NGS data analysis Molecular Modelling, Drug Discovery & Molecular Dynamic Simulation	Publications including conference Publications : Kumar, R., Ojha, K. K., Kushwaha, P., & Singh, V. K. (2020). Muscle biopsies differ in relation to expression of fiber-type specific genes. Journal of Diabetology, 11(3), 198. Pratika Singh. Azmi Khan. Rakesh Kumar. Ravinsh Kumar. Vijay Kumar Singh. Amrita Srivastava. (2020). Recent developments in siderotyping: procedure and application. World Journal of Microbiology and Biotechnology. 36:178. Prasanna, P., Kumar, R., Singh, V. K., & Upadhyay, A. (2021). Cloning, purification, and homology modeling of Histone deacetylase in Leishmania donovani. Infection, Genetics and Evolution, 104738. Rakesh Kumar and Vijay Kumar Singh. Investigation of type 2 diabetic responsive genes based on a set of highly co-expressed genes: National Workshop on Big Data and Artificial Intelligence in Biotechnology and Healthcare. (2019). Rakesh Kumar, Krishna Kumar Ojha and Vijay Kumar. Investigation of molecular interaction between A-beta and insulin receptors: An In-silico study. 23rd international conference of the international academy of physical sciences (coniaps xxiii) on advances in physical sciences to achieve sustainable development goals.(2018) Rakesh Kumar and Vijay Kumar Singh. Identification of Hidden Patterns in Gene Expression Data, Given Gene set a Priori: An Application to Diabetes GEPs. VIII International Symposium on Statistics and Optimization in conjunction with XXXVI-Annual Convention of Indian Society for Probability & Statistics (ISPS) and Seminar on Statistical Inference, Sampling and Optimization Techniques & Related Areas. (2016) Rakesh Kumar and Anil Kumar. In silico interaction studies of Resveratrol derivatives with human tyrosinase.1st International Conference on Human Implications of Biotechnology. (2016)
2	Sonu Kumar CUSB1503175002 sonukumar@cub.ac.in Contact: +919835431433	Dr. Asheesh Shanker	M.Phil. in Bioinformatics	Bioinformatics & Genomics	Publications Sonu Kumar and Asheesh Shanker (2018) Common, unique, and polymorphic simple sequence repeats in chloroplast genomes of genus Arabidopsis. Vegetos- An International Journal of Plant Science. 31(Special): 125-131. Sonu Kumar and Asheesh Shanker (2018) Bioinformatics resources for the stress biology of plants. In Biotic and Abiotic Stress Tolerance in Plants. Springer, Singapore. (pp. 367-386). Sonu Kumar and Asheesh Shanker (2018) Biological databases for medicinal plant research. In Biotechnological Approaches for Medicinal and Aromatic Plants. Springer, Singapore. (pp. 655-665). Khushbu Anand, Sonu Kumar, Afroz Alam, and Asheesh Shankar (2019) Mining of microsatellites in mitochondrial genomes of order Hypnales (Bryopsida). Plant Science Today. 6 (sp1): 635-638. Sonu Kumar and Asheesh Shanker (2020) Analysis of microsatellites in the mitochondrial genome of Aneura pinguis (L.) Dumort. In Contemporary Research on Bryophytes. Bentham Science Publishers Pte. Ltd. Singapore. (pp. 20-37). Sonu Kumar and Asheesh Shanker (2020) Computational resources for bryology. In Contemporary Research on Bryophytes. Bentham Science Publishers Pte. Ltd. Singapore. (pp. 20-37). Sonu Kumar and Asheesh Shanker (2020) In silico comparative analysis of simple sequence repeats in chloroplast genomes of genus Nymphaea. Journal of Scientific Research. 64(1): 186-192. Sonu Kumar and Asheesh Shanker (2020) Length variation of chloroplast simple sequence repeats in the genus Eucalyptus L'Hér. Plant Science Today. 7(3): 353-359. Sonu Kumar, Kriti Kumari, Anamika Singh, Keshav Kumar, Ashutosh Singh, and Asheesh Shanker (2020) Development and analysis of simple sequence repeats in chloroplast genomes of genus Saccharum: a computational study. In Recent Trends in ‘Computational Omics’. Nova Science Publishers, Inc. Sonu Kumar, Swati Kumari, and Asheesh Shanker (2020) In Silico Mining of Simple Sequence Repeats in Mitochondrial Genomes of Genus Orthotrichum. Journal of Scientific Research. 64(2): 179-182.
3	Agnik Haldar halderagnik@gmail.com agnikhaldar@cusb.ac.in CUSB1803375001	Dr. Ajay Kumar Singh	M.Tech. Bioinformatics	Functional Genomics, Transcriptomics, Statistical NGS Data Analysis, Cancer informatics	Publications Haldar A, Mitra S, Chakrabarti J. Perspective on long noncoding RNA functionality. Transl Cancer Res 2017;6 S1049-S1053. doi: 10.21037/tcr.2017.07.20 Sayak Ganguli, Mitra Sanga, Halder Agnik, Gupta Sohini, Chakrabarti Jayprokas. (2017). Databases: a comprehensive resource of noncoding RNAs. Cancer and Non Coding RNAs. Mitra Sanga, Halder Agnik, Gupta Sohini, Sayak Ganguli, Chakrabarti Jayprokas. (2018). A Comparative Evaluation of Emerging Databases and Tools for Cancer Noncoding RNAs. Cancer and Non Coding RNAs. Academic Press. 10.1016/B978-0-12-811022-5.00027-9. Haldar A., Mandal R. (2018) A transcriptomic approach towards understanding virulence regulation of Salmonella serovars Typhi, Typhimurium and Paratyphi A. Haldar A., Yadav K., Katara P.C., Singh A.K.. (2020) Bioinformatics resources for the prediction of cancer prognosis and its recurrence. Recent trends in computational omics, concepts and Methodology. Nova Science Publishers, U.S.A Haldar A., Singh A.K.. (2020) Next-generation sequence analysis for clinical applications. Translational Bioinformatics Applications in Healthcare. CRC Publication. Conferences Haldar A., Singh A.K.* A transcriptomic analysis on long non coding RNA role in oral cancer inhibition. National Conference on Biological, Biochemical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021), conducted by Department of Biotechnology National Institute of Technology Warangal, Telangana, India Awards University Gold Medal in Masters of Engineering, 2018 (for highest academic standing at postgraduate level) Best Oral Presentation Award Haldar A., Singh A.K.* A transcriptomic analysis on long non coding RNA role in oral cancer inhibition. National Conference on Biological, Biochemical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021), conducted by Department of Biotechnology National Institute of Technology Warangal, Telangana, India
4	Bikash Kumar rajak bikash@cusb.ac.in bkrbikash0@gmail.com CUSB1803375001	Dr. Durg Vijay Singh	B.Sc. Botany Hons. M.Sc. Bioinformatics	Molecular Dynamics Simulation and Computer-aided Drug Discovery	Publication/conference Rajak, B.K, Rani. P., Mandal.P. and Singh, D.V 2021, January. “Identification of lead molecule against Acetyl-CoA Carboxylases of Phalaris minor” National Conference on Biological, Biochemical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021), conducted by Department of Biotechnology National Institute of Technology Warangal, Telangana, India (Got Best Oral Presentation Award) Rani.P, Rajak, B.K 2021, Mandal,P. Singh D.V January. “Discovery of Lead Herbicide Molecules Against ACCase Protein of Phalaris Minor” National-e Conference on Bioremediation and Detoxification of Environmental Pollutants” organised by Department of Zoology Lalit Narayan Mithila University Darbhanga, Bihar India
5	Keerti Kumar yadav keerti@cusb.ac.in 7836071067	Dr. Ajay Kumar Singh	M.Tech Bioinformatics	Systems Biology,Cancer informatics, CADD	Sikka P, Nath A, & Yadav KK. (2016). Insilico characterization of novel PH20 hyaluronidase protein sequences of murrah (Bubalus bubalis) bulls. Applied Biological Research, 18(2), 171-177 Haldar A, Yadav KK, Katara P, Singh AK, (2020). “Bioinformatics resource for prediction of cancer prognosis and it’s recurrence, Recent trends in computational omics concepts and methodologies “, NOVA Science Publication Yadav KK, Singh AK, ”Oral cancer identification candidate genes by integrated Protein-Protein interaction and Systems biology approach” Two Day Online National Conference on Biological, Biochemical, Biomedical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021) held on 29-30 January 2021
6	Kiran Kr A kirankumar@cusb.ac.in	Prof. R.S Rathore	M.Sc.Biochemistry	Molecular Modeling & Drug Design	GATE Qualified. Publications including conference Publications: Kiran Kr A kirankumar@cusb.ac.in Angamba Meetei Potshangbam, Potshangbam Nongdam, A. Kiran Kumar and R.S. Rathore, “Phenylbenzopyrone of flavonoids as a potential scaffold to prevent SARS-CoV-2 replication by inhibiting its MPRO main protease”, Current Pharmaceutical Biotechnology (2021)22:1. Kiran kumar. A, R.S Rathore, R.S Upadhyayula. Characteristic differences at the interfacial hotspot regions of the protein-protein and protein-peptide complexes (2021). Ganga Bhavani. D., Muni Kumari. A and Kiran Kumar. A (2015). Chikckpea Endophytic Bacteria Inhibiting Dry Root Rot Fungus Rhizoctonia bataticola. International Journal of Scientific and Engineering Research. 6(2): 83-85.ISSN:2229-5518. Kiran Kumar.A, Characterization of Protein-Protein and Protein-Peptide Interactions: Implication for Biologics Design (February 2, 2020). Proceedings of International Conference on Drug Discovery (ICDD) 2020. Kiran Kumar. A, Machine learning Prediction of Transient and Permanent Protein Interactions using Weka (January 29-30, 2021). Proceedings of Two-Day Online National Conference on Biological, Biochemical,Biomedical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021) A. Kiran Kumar and Dr. A. Muni Kumari.Effect of Lipoxygenase enzyme to downy mildew disease in Foxtail Millet’ Proceedings of International Conference on Advances in Plant and Microbe Research (ICAPMR 2016)Acharya Nagarjuna University, Guntur, A. P A. Kiran Kumar and Dr. A. Muni Kumari. ―’Lox in Resistance of foxtail millet to Blast Infection’ Proceedings of UGC Sponsored National Seminar on Emerging Trends in Genetics and Genomics Research 13-14 February 2014. Dept of Genetics and Genomics Yogi Vemana University, Kadapa, A.P.
7	Praffulla Kumar Arya CUSB1803375005 praffullaarya@cusb.ac.in Mobile: 7979031632	Dr. Anil Kumar	M.Sc. Bioinformatics	Biological Database Development	Chapter Publications Kumar, A., & Arya, P, (2020). Database Resources for Cyanobacterial Research. In P. K. Singh & A. K. Shrivastava (Authors), Advances in cyanobacterial biology (1st ed., pp. 47-54). London, United Kingdom: Academic Press. Kumar, A., & Arya, P, (2020). Database Resource for Drug Discovery. In D.B. Singh (Authors), Computer-aided drug design. Springer Nature, Singapore.
8	Kriti Kumari kriti@cusb.ac.in	Dr. Asheesh Shanker	M.Sc Bioinformatics	Evolutionary biology and computer-aided drug discovery	Sonu Kumar, Kriti Kumari, Anamika Singh, Keshav Kumar, Ashutosh Singh, and Asheesh Shanker (2020) Development and analysis of simple sequence repeats in chloroplast genomes of genus Saccharum: a computational study. In Recent Trends in ‘Computational Omics’. Nova Science Publishers, Inc.
9	Pranabesh Mandal pranabesh@cusb.ac.in Mobile: 7908836982	Dr. Durg Vijay Singh	M.Sc. Bioinformatics	Molecular Dynamics Simulation and Computer-aided Drug Discovery	Awards received: -Best Poster Presentation Award- Rani, P., Mandal, P., & Singh, D.V., 2019, November. Efficacy of rationally synthesised herbicides in Phalaris minor susceptible and resistant weeds of wheat crop. 1 st National Agrochemicals Congress: County’s Status on Various Fronts of Agrochemicals, ICAR-Indian Agricultural Research Institute-New Delhi.
10	Priyanka rani priyanka.rani.453@gmail.com priyanka@cusb.ac.in	Dr. Durg Vijay Singh	B.Sc. Industrial microbiology (2015) M.Sc. Bioinformatics (2017)	Structural biology, Molecular modelling, Molecular docking, Dynamics study, Computer Aided-Drug discovery Microbiology	Published research articles: Rani, P., Kumari, P., & Swayamprabha, S. (2015). Comparison between chemical and natural disinfectant against Escherichia coli and Streptococcus pyogenes. IRIS, V: 45-51. Bera, K., Rani, P., Kishor, G., Agarwal, S., Kumar, A., & Singh, D. V. (2018). Structural elucidation of transmembrane domain zero (TMD0) of EcdL: A multidrug resistance-associated protein (MRP) family of ATP-binding cassette transporter protein revealed by atomistic simulation. Journal of Biomolecular Structure and Dynamics, 36(11), 2938-2950. Rani, P., Kumari, J., Agarwal, S., & Singh, D. V. (2019). Binding mode of aryloxyphenoxypropionate (FOP) and cyclohexanedione (DIM) groups of herbicides at the carboxyl transferase (CT) domai of Acetyl-CoA carboxylase of Phalaris minor. Network Modeling Analysis in Health Informatics and Bioinformatics, 8(1), 1-14. Conferences: -Oral Presentation- Rani, P., Nijeta., & Singh, D.V., 2018, November. Strategic development of herbicide to combat the massive problem of Phalaris minor weed, through computational approach. ISWS Golden Jubilee Conference; hald at ICAR-Directorate of Weed Research, Jabalpur. -Poster Presentation- Rani, P., & Chakarborty, S.S., 2018, August. In silico drug design using pharmacophore modeling, virtual screening, and molecular docking to design inhibitors against human Bone Morphogenetic Protein-1 as new lead molecules for therapy. Two days international seminar on Recent trends in science towards sustainable development, Indian Chemical Society, Acharya Prafulla Chandra College, Kolkata. Rani, P., Mandal, P., & Singh, D.V., 2019, November. Efficacy of rationally synthesised herbicides in Phalaris minor susceptible and resistant weeds of wheat crop. 1 st National Agrochemicals Congress: County’s Status on Various Fronts of Agrochemicals, ICAR-Indian Agricultural Research Institute-New Delhi. Rajak, B.K., Rani, P., Mandal, P., & singh, D.V. 2021, January. Identification of lead molecule against Acetyl-CoA Carboxylases Of Phalaris minor. National Conference on Biological, Biochemical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021). Department of Biotechnology, National Institute of Technology Warangal, Telengana-India. Rani, P., Rajak, B.K., Mandal, P., & Singh, D.V., 2021 January. Discovery of lead herbicide molecules against ACCase protein of Phalaris minor. National e-conference: Bioremediation and Detoxification of Environmental Pollutants, Department of Zoology, Lalit Narayan Mithila University, Darbhanga-Bihar. Awards received: -Best Poster Presentation Award- Rani, P., Mandal, P., & Singh, D.V., 2019, November. Efficacy of rationally synthesised herbicides in Phalaris minor susceptible and resistant weeds of wheat crop. 1 st National Agrochemicals Congress: County’s Status on Various Fronts of Agrochemicals, ICAR-Indian Agricultural Research Institute-New Delhi.
11	SM Shayez karim	Prof. R.S Rathore	M.Tech Bioinformatics	Brain Connectome Analysis
12	Suchitra Singh suchitrasingh@cusb.ac.in CUSB1903375006	Dr.Ajay Kumar Singh	M.Sc Bioinformatics	Molecular modelling and Drug Design	Publications and Conferences Singh, S., & Singh, A. K. (2020). Mutated USP9X-Associated TRIM33 Inhibition in the Metastasis of Gingivobuccal Oral Squamous Cell Carcinoma Eurasian Journal of Medicine and Oncology (EJMO), 4(4):309-318 Singh S., Singh A.K., Porphyromonas gingivalis virulence factors Inhibitors screening in oral squamous cell carcinoma (OSCC) Two Day Online National Conference on Biological, Biochemical, Biomedical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021) held on 29-30 January 2021
13	Sumanta kumar Sahu sumanta@cusb.ac.in Mob:9937209313	Dr. Krishna Kumar Ojha	M.Sc. Bioinformatics	Rational Drug Design & QSAR
14	Gyan Prakash Rai Email: gyanprakash@cusb.ac.in Mob:8860759395	Dr. Asheesh Shanker	M.Sc. Bioinformatics
15	Mayank Kumar Email mayank2801@gmail.com Contact 9308953868	Prof. R.S. Rathore	Master in Computer Application	Protein Structure Prediction	UGC - NET (June 2020 ) Qualified
16	Kirshnendu Krishnendubarik@gmail.com 7008641931	Dr Anil kumar	MSc Bioinformatics	Biological Database Development
17	Niharika niharika@cusb.ac.in 8228934884	Dr.Vijay Kumar Singh	MSc. Bioinformatics	Transcriptomics
18	Piyush kumarpiyush285@gmail.com CUSB2003375005	Dr. Ajay Kumar Singh	M.tech Bioinformatics	Drug Discovery	Oral Presentation Piyush K Yadav, Ajay K Singh* ‘Hepcidin as iron chelation target in Beta thalassemia Major : An in-silico approach’ Two Day Online National Conference on Biological, Biochemical, Biomedical, Bioenergy and Environmental Biotechnology (NCB4EBT-2021) held on 29-30 January 2021 Piyush K Yadav, Ajay K Singh* ‘Iron overload targets and their effects in Beta-thalassemia major’ Two day International Conference on Frontier Areas of Chemistry held on 28-29 Feb 2020

Post Graduate Students

MSc (2021-23) Batch

r. No.	Enrolment_No	NAME OF THE APPLICANT	EMAIL
1	CUSB2103312001	ABHISHEK CHOUDHARY	choudharyabhi3120@gmail.com
2	CUSB2103312002	ABHISHEK KUMAR	abhishekkumar141099@gmail.com
3	CUSB2103312003	AFSA NAAZ	ehsankaisal@gmail.com
4	CUSB2103312004	ANIRUDDHYA MUKHERJEE	aniruddhya08@gmail.com
5	CUSB2103312005	ANKITA SUBHADARSANI PARIDA	ankitasubhadarsaniparida@gmail.com
6	CUSB2103312006	ANMOL SHARMA	anmolsharma7121@gmail.com
7	CUSB2103312007	ANSHUL VERMA	anshulverma2k1@gmail.com
8	CUSB2103312008	FIZZA KHAN	khanfizza27@gmail.com
9	CUSB2103312009	HARSH KUMAR	mohitraj9576@gmail.com
10	CUSB2103312010	HASEEB AHMAD	haseebahmad789@gmail.com
11	CUSB2103312011	JAGRITI SHUKLA	jagritip.s12@gmail.com
12	CUSB2103312012	JYOTI MURMU	murmujyoti47@gmail.com
13	CUSB2103312013	KOPAL SINGH	kopal.somvanshi@gmail.com
14	CUSB2103312014	KRUTIDEEPA ROUT	krutirout002@gmail.com
15	CUSB2103312015	NEHA KUMARI	nehakr20aug@gmail.com
16	CUSB2103312016	NISHANT RAJ	nisntraj@gmail.com
17	CUSB2103312017	PALLAVI SINGH	words.florence@gmail.com
18	CUSB2103312018	PRABIR BARMAN	barmanprabir02@gmail.com
19	CUSB2103312019	RAVI SHANKAR SHARMA	Mr.ravishankar.sharma@gmail.com
20	CUSB2103312020	REDAM SAHA	redamsaha555@gmail.com
21	CUSB2103312021	RITIKA SINGH	ritikaa198@gmail.com
22	CUSB2103312022	SAFEER KHAN	ksafeer098@gmail.com
23	CUSB2103312023	SAURAV KUMAR	Kumarsaurav787059@gmail.com
24	CUSB2103312024	SHREYA BHARDVAJ	bhardwajshreya175@gmail.com
25	CUSB2103312025	SONALI SINHA	sonalsonali.sinha@gmail.com
26	CUSB2103312026	SREESHMA RAJ K	sreeshmaraj72@gmail.com
27	CUSB2103312027	SUBHASHREE SAHU	sushreeshruti440@gmail.com
28	CUSB2103312028	SUGAM KUMAR PATEL	ptlsugam@gmail.com
29	CUSB2103312029	SUMAIYA KHATUN	sumi15live@gmail.com
30	CUSB2103312030	SUMAN KUMARI	pushpraj.vishwajeet@gmail.com
31	CUSB2103312031	SUSHREE ADARSHEE SAHU	adarsheea@gmail.com
32	CUSB2103312032	SWETA	swetasingh.7jan@gmail.com
33	CUSB2103312033	YUKTI SINGH	singhyukti7@gmail.com

	MSc(2020-22)	Batch
	Enrolment No.	Name of Student	E-mail of student(personal)
1	CUSB2003312001	ANANYA KASHYAP	kashyapananya46@gmail.com
2	CUSB2003312002	ANNAPURNA KUMARI	annapurnakumari945@gmail.com
3	CUSB2003312003	ANWESHA DHAL SAMANTA	dhalanwesha9@gmail.com
4	CUSB2003312004	ASHISH PRATIM MAHANTA	ashishpratim@gmail.com
5	CUSB2003312005	ATUL ABHISHEK	atulabhishek2010@gmail.com
6	CUSB2003312006	GARIMA KUMARI	kgarima147@gmail.com
7	CUSB2003312007	GAURAV KUMAR	gauravguptasatsa@gmail.com
8	CUSB2003312008	H KIRAN	kiranrekhahari@gmail.com
9	CUSB2003312009	KISHAN KUMAR	kkishan593@gmail.com
10	CUSB2003312010	MADHVI KUMARI SINHA	madhukrsinha31@gmail.com
11	CUSB2003312011	MANAVI KUMARI	manavikumari9@gmail.com
12	CUSB2003312012	MANISHA MOHANTA	munnamohanta71686@gmail.com
13	CUSB2003312013	NISHANT SHEKHAR	nishant.shekhar776@gmail.com
14	CUSB2003312014	POOJA KUMARI	pkri7225@gmail.com
15	CUSB2003312015	PRIYANSU BEHERA	pbpriyansu@gmail.com
16	CUSB2003312017	RAJESH MISHRA	shakhtlaunda1509@gmail.com
17	CUSB2003312018	SHRABANTI ACHARYA	aloke.kumar28@gmail.com
18	CUSB2003312023	TRISHULA MITRA	trishulamitra@gmail.com

19	CUSB2003312026	Rashmi Kumari	rashmikri1819@gmail.com

Department Alumni

Alumini Details MSc (2011-onwards)

Project
1. Dr. Durg Vijay Singh PI, UGC (2013-15; 6 lacs) project entitled Design and development of inhibitors against Nucleotide Binding Domain of P-gp for enhancing Bioavailability and reversal of multidrug resistance
2. Dr. Durg Vijay Singh, PI, DST Kiran (2014-15; 3.26 lacs) project entitled Design and Development of herbicide against carboxyl-terminal (CT) domain of ACCase of P.minor to regain resistivity in resistance biotypes
3. Dr. Vijay Kr. Singh PI, SERB (2016-20; 14 Lakh) project entitled Identification of molecular species that have potential to compete with insulin for receptor binding
4. Dr. Durg Vijay Singh PI DST-SERB (2016-19; 31 lacs) project entitled Design and Development of Herbicide to Regain Sensitivity in Phalaris Minor Resistant Biotypes
5. Dr. Ajay Kr. Singh, PI Dr. Anil Kumar (Co-PI) ICMR (2019-Ongoing; 35 lacs) project entitled In-Silico study on potent inhibitors against iron overload and cardiac arrhythmia in beta-thalassemia (RP-56).
6. Dr. Durg Vijay Singh (PI) and Dr. Girish Chandra (Co-PI) ICMR (2020-ongoing; 31 lacs) project entitled Rational approach of antibiotic discovery and development against, a staphylococcus aureus serine-threonine phosphatases (Stp) protein (Project ID RP-60).
7. Dr. Vijay Kr. Singh Dr. K.K. Ojha (Co-PI) ICMR (2020-Ongoing; 20 lacs) project entitled Gene interaction landscape inferred from expression data to search for diabetes effector molecules (Ref. 2020-3854)
8. Dr. Durg Vijay Singh (PI), Prof. RS Rathore (Co-PI), Dr. Girish Chandra (Co-PI) (2021 Ongoing 50.37 Lakh) Development of herbicides against Acetyl CoA Carboxylase to address resistance and cross-resistance against Phalaris minor: A weed of wheat crop field.”
Specific areas of research
Disease Biology using modeling and omics approaches: The research in the Department of Bioinformatics, is primarily focused towards understanding the underlying process in disorders, with special emphasis on neurodegenerative, respiratory, monogenic & metabolic disorders, infectious disease & cancer.
1. New algorithms and database have been developed to provide solution for drug and biologics design such as Databases of therapeutic targets and novel leads pertaining to natural products (MedPServer), de novo peptide design (Conflore), curcumin analogs and their molecular & disease targets (CRDB), a workflow for complete 3D-QSAR modeling, virtual screening & design (3D-QServer), simple sequence repeats database, and online server to detect simple sequence repeats with length variation etc.
2. Analysis of muscle transcriptome to identify biologically relevant class of diabetic patient: We are analyzing large transcriptome datasets to identify subset of diabetic subjects having homogeneous expression of genes related to selected biological processes/pathways.
3. Genome characterization of gall bladder cancer from Indo-Gangetic belt of India
4. Evolutionary sequence analysis to detect drug resistance in pathogens
5. Role of lnc RNA in oral and cervical cancer to understand the mechanism and its significance in oncogenesis.
6. In silico study on potent inhibitors against iron overload and Cardiac arrhythmia in beta thalassemia
7. Development (Design, Synthesis and Biological Evaluation) of novel Dual-binding Cation-π Inhibitors of AChE:
8. Design of flavonoid based SARS-CoV-2 MPRO inhibitors
9. Identification of Herb-based Lead Molecules, Optimization and Testing using case study of herbs available in Indian sub-continent for Asthma & Respiratory-tract Infection
10. Other areas:
  Design and development of active molecule against herbicide resistance weeds & validation of leads through wet-lab and field assay as multiple and cross resistances in weeds is a major threat in grain production.
  o Comparative genomics of prokaryotes: To estimate the origin of replication site based on the nucleotide frequency of the prokaryotic genomes.
Research Publications
2022
1. Haldar, A., Singh, A.K. The association of long non-coding RNA in the prognosis of oral squamous cell carcinoma. Genes Genom (2022). https://doi.org/10.1007/s13258-021-01194-w.
2021
1. PA Meetei, P. Nongdam, A Kiran Kumar, RS Rathore., (2021), Phenylbenzopyrone of flavonoids as a potential scaffold to prevent SARS-CoV-2 replication by inhibiting its M PRO main protease. Current Pharmaceutical Biotechnology. In press.
2. Mahesha N, Yathirajan HS, Nagma Banu HA, Kalluraya B, Rathore RS and Glidewell CG. Formation of 1-(thiazol-2-yl)-4,5-dihydropyrazoles from simple precursors: synthesis, spectroscopic characterization and the structures of an intermediate and two products. Acta Crystallographica Section E: Crystallographic Communications (IUCr/Wiley). (2021). E77, 975-981
3. Prasanna, P., Kumar, R., Singh, V. K., & Upadhyay, A. (2021). Cloning, purification, and homology modeling of Histone deacetylase in Leishmania donovani. Infection, Genetics and Evolution, 104738. (IF - 2.77)
4. Priya P, Shanker A (2021) Coevolutionary forces shaping the fitness of SARS-CoV-2 spike glycoprotein against human receptor ACE2. Infection, Genetics and Evolution 87: 104646
5. Nandan Kumar, Priyanka Rani, Shikha Agarwal Durg Vijay Singh "6-Ethoxy-4-N-(2-Morpholin-4-Ylethyl)-2-N-Propan-2- yl-1,3,5-Triazine-2,4-Diamine Endows Herbicidal Activity Against Phalaris Minor a Weed of Wheat Crop Field: An in-Silico and Experimental Approaches of Herbicide Discovery" Journal of molecular modeling 2021 (Accepted)
2020
1. An in silico approach to identify potential medicinal plants for treating Alzheimer disease: a case study with acetylcholinesterase, AM Potshangbam, A Nandeibam, T Amom, N Potshangbam, H Rahaman, RS Rathore, Journal of Biomolecular Structure and Dynamics, 1-13 (2020) in press
2. Fifteen 4-(2-methoxyphenyl) piperazin-1-ium salts containing organic anions: supramolecular assembly in zero, one, two and three dimensions, C Harish Chinthal, CN Kavitha, HS Yathirajan, S, RS Rathore, C.G. Glidewell, Acta Crystallographica Section E: Crystallographic Communications 76 (11) 2020.
3. K Kumar Reddy, R S Rathore , P Srujana, R R Burri, C Ravikumar Reddy, M Sumakanth, Pallu Reddanna, M Rami Reddy, Mini Rev Med Chem. 2020;20, 1179-1187. Performance Evaluation of Docking Programs- Glide, GOLD, AutoDock & SurflexDock, Using Free Energy Perturbation Reference Data: A Case Study of Fructose-1, 6-bisphosphatase-AMP Analogs. doi: 10.2174/1389557520666200526183353.
4. Kiran Kumar, H. S. Yathirajan, Asma, N. Manju, B. Kalluraya, R. S. Rathore and C. Glidewell (2020) Acta Crystallographica E (Wiley/IUCr). E76, 683-691. Functionalized 3-(5-aryloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(4-substituted-phenyl)prop-2-en-1-ones: synthetic pathway, and the structures of six examples. https://doi.org/10.1107/S2056989020005113
5. Naresh Damuka, K. Kurumurty, P. Angamba Meetei, R.S. Rathore, A.K. Kondapi and V. Vindal, (2020) Pharmacological Reports (Springer Nature). In press. Discovery of Dual Cation-π Inhibitors of Acetylcholinesterase: Design, Synthesis and Biological Evaluation. https://doi.org/10.1007/s43440-020-00086-2
6. Angamba Meetei, R.S. Rathore, P. Nongdam, (2020) Heliyon (Cell Press) 6(2), e033782019. Discovery of sulfone-resistant dihydropteroate synthase (DHPS) as a target enzyme for kaempferol, a natural flavonoid. https://doi.org/10.1016/j.heliyon.2020.e03378
7. A.E. Shaibah, H.S. Yathirajan, N. Manju, B. Kalluraya, R.S. Rathore, C. Glidewell (2020) Acta Crystallographica E (Wiley/IUCr) E76, 48-52. Two isostructural 3-(5-aryloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(thiophen-2-yl)prop-2-en-1-ones: disorder and supramolecular assembly. https://doi.org/10.1107/S205698901901658X
8. A. E. Shaibah, H. S. Yathirajan, Asma, N. Manju, B. Kalluraya, R. S. Rathore and C. Glidewell, (2020) Acta Crystallographica E (Wiley/IUCr) E76, 360-365. Conversion of diarylchalcones into 4,5-dihydropyrazole-1-carbothioamides: molecular and supramolecular structures of two precursors and three products. https://doi.org/10.1107/S2056989020001735
9. Jayaswal PK, Shanker A, Singh NK (2020) Genome wide annotation and characterization of young, intact long terminal repeat retrotransposons (In-LTR-RTs) of seven legume species. Genetica 148: 253-268.
10. Kumar S, Kumari S, Shanker A (2020) In silico mining of simple sequence repeats in mitochondrial genomes of genus Orthotrichum. Journal of Scientific Research 64: 179-182.
11. Kumar S, Shanker A (2020) Length variation of chloroplast simple sequence repeats in the genus Eucalyptus L’Hér. Plant Science Today 7(3): 353-359
12. Jayaswal PK, Shanker A, Singh NK (2020) Genome-wide comparative and evolutionary analysis of transposable elements in eight different legume plants Indian Journal of Agricultural Sciences 90: 1025-1031.
13. Kumar S, Shanker A (2020) In silico comparative analysis of simple sequence repeats in chloroplast genomes of genus Nymphaea. Journal of Scientific Research 64: 186-192.
14. Suchitra Singh & AK Singh (2020) Mutated USP9X-Associated TRIM33 Inhibition in the Metastasis of Gingivobuccal Oral Squamous Cell Carcinoma EJMO. 2020; 4(4): 309-318
15. Kamboj M., Jain K., Singh D.P., Singh A.K. Chaturvedi D^e., Molecular modeling, in-silico docking and antibacterial studies of novel template wangled macrocyclic complexes involving isatin moiety. Journal of Molecular Structure, Elsevier, 2020 (1207) Volume 1207, 5 May 2020, 127602 (Impact Factor 2.120).
16. Rani, S., Singh, A.K., Paswan, R.R. et al. Preparation, Characterization and Antibacterial Evaluation of Soy Protein Isolate Biopolymeric Films Loaded with Nalidixic Acid. J Polym Environ (2020). 28, 1841–1850(2020). [Impact Factor 2.896].
17. Tiwari S.K., Singh A.K., Singh A (2020). In-silico primer designing and PCR for detection of novel coronavirus-19, Journal of Infection and Public Health, (2020) 13(12), 1885-1886. Elsevier. (Impact factor : 2.447)
18. Chandra G., Patel S., Panchal M., Singh D.V. (2020) S-Adenosyl-L-homocysteine hydrolase: Its Inhibitory Activity against Plasmodium falciparum and Development of Malaria Drugs. Mini Rev Med Chem . doi: 10.2174/1389557521666201218155321. (I.F.-3.0
19. Singh, P., Khan, A., Kumar, R., Kumar, R., Singh, V. K., & Srivastava, A. (2020). Recent developments in siderotyping: procedure and application. World Journal of Microbiology and Biotechnology, 36(12), 1-15. (IF - 2.44).
20. Rai, N. K., Mathur, S., Singh, S. K., Tiwari, M., Singh, V. K., Haque, R.,Tiwari, S., & Sharma, L. K. (2020). Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells. Oncology letters, 20(6), 1-1.
21. Kumar R, Ojha KK, Kushwaha P, Singh VK. Muscle biopsies differ in relation to expression of fiber‐type specific genes. J Diabetol 2020;11:198‐203
Patent
1. Title:6-ethoxy-4-n-(2-morpholin-4-ylethyl)-2-n-propan-2-yl-1,3,5-triazine-2,4-diamine endowed with herbicidal activity against susceptible and resistant biotypes of Phalaris minor. Inventor: Durg Vijay Singh et.al., (2020). Field of Invention: Pharmaceuticals

E-Resources for Courses

Course Code	Course Name	Question papers (Previous Years)	Notes and Presentations	Video and Suggested readings
MSBIS1001C04	Introduction to Bioinformatics	2021 2020 2019	Lecture-1 Lecture-2
MSBIS1002C04	Cell and Molecular Biology	2021 2020 2019	Lecture-1 Lecture-2
MSBIS1003C04	Mathematics and Statistics with R	2021 2020 2019	Lecture-1 Lecture-2
MSBIS1004C04	Linux and Shell Programming	2021 2020 2019	Lecture-1 Lecture-2
MSBIS1005C04	Programming with C	2021 2020 2019	Lecture-1 Lecture-2
MSBIS2001C04	Algorithms in Bioinformatics	2021 2020 2019	Lecture-1 Lecture-2
MSBIS2002C04	Biomolecular Modelling & Simulations	2021 2020 2019	Lecture-1 Lecture-2
MSBIS2003C04	Programming with Perl	2021 2020 2019	Lecture-1 Lecture-2
MSBIS2004C04	Genetics and Genomics	2021 2020 2019	Lecture-1 Lecture-2
MSBIS2005C04	Evolution and Molecular Phylogeny	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3001C04	Chemoinformatics and Drug Design	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3002C04	Transcriptomics and Proteomics	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3003C04	DBMS and Web Technology	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3004C04	Minor Project (Review of Literature, Seminar, and Research Problem Definition)	2021 2020 2019	Lecture-1 Lecture-2
MSBIS1001E04	Biochemistry and Immunology	2021 2020 2019	Lecture-1 Lecture-2
MSBIS2001E04	Whole exome sequencing data analysis	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3001E04	Big Data Analytics and Health Informatics	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3002E04	Programming with Python	2021 2020 2019	Lecture-1 Lecture-2
MSBIS3003E04	Systems Biology	2021 2020 2019	Lecture-1 Lecture-2